Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic

Title: Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic
Creator: Sominsky, L.; Walker, A. K.; Ong, L. K.; Tynan, R. J.; Walker, F. R.; Hodgson, D. M.
Relation: Behavioural Brain Research Vol. 226, Issue 1, p. 351-356
Publisher Link: http://dx.doi.org/10.1016/j.bbr.2011.08.038
Publisher: Elsevier BV
Resource Type: journal article
Date: 2012
Description: Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour in adulthood. Our current aim was to examine whether neonatal LPS exposure is associated with changes in microglial activation, and whether these alterations correspond with alterations in behaviour. In adulthood, LPS-treated animals exhibited significantly increased anxiety-like behaviour and hippocampal microglial activation. The efficacy of the LPS challenge was confirmed by increased neonatal plasma corticosterone and tyrosine hydroxylase (TH) phosphorylation in the adrenal medulla. These findings suggest a neuroimmune pathway which may underpin the long-term behavioural and neuroendocrine changes following neonatal infection.
Subject: LPS; postnatal; anxiety behaviour; HPA axis; TH phosphorylation; microglial activation; hippocampus
Identifier: http://hdl.handle.net/1959.13/1309028
Identifier: uon:21747
Identifier: ISSN:0166-4328
Language: eng
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